Interdomain Flexibility in Full-length Matrix Metalloproteinase-1 (MMP-1)
نویسندگان
چکیده
منابع مشابه
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.
The multidomain zinc endopeptidase matrix metalloproteinase-9 (MMP-9) is a recognized therapeutic target in autoimmune diseases, vascular pathologies, and cancer. Despite its importance, structural characterization of full-length pro-MMP-9 is incomplete. Here, we report the structural model of full-length pro-MMP-9 and, in particular, the molecular character of its unique proline-rich and heavi...
متن کاملangiotensin ii differentially induces matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 production and disturbs mmp/timp balance
angiotensin ii, the main component of the renin-angiotensin system, is associated with cardiovascular diseases such as hypertension, vascular remodeling and inflammation. remodeling process results from dysregulation of matrix metalloproteinases (mmps) and their tissue inhibitors (timps). mmps are considered as important target genes for angiotensin ii. the aim of this study was to determine th...
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PURPOSE To study levels and activity of matrix metalloproteinase (MMP)-1 and -9 and their tissue inhibitor (TIMP-1) in tears of patients with vernal keratoconjunctivitis (VKC), with and without severe corneal damage. METHODS Tear samples were obtained from 16 patients with active VKC and 10 normal control subjects, after clinical evaluation and tear cytology. Tear levels of pro-MMP-1, pro-MMP...
متن کاملRapid communication: a BstXI polymorphism in the porcine matrix metalloproteinase 1 (MMP-1) gene locus.
1This project is supported by grants from the National Natural Science Foundation of China; Ministry of Agriculture, China, and Sino-German Agricultural Cooperation Program. 2Present address: Centre for Genetic Improvement of Livestock, Dept. of Anim. and Poult. Sci., Univ. of Guelph, Guelph, Ontario N1G 2W1 Canada. 3To whom correspondence should be addressed (phone: 08161 71 3746; E-mail: rott...
متن کاملRole of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis.
Extracellular matrix (ECM) proteins, their integrin receptors, and matrix metalloproteinases (MMPs), the ECM-degrading enzymes, are believed to be involved in various biological processes, including embryogenesis. In the present study, we investigated the role of membrane type MMP, MT-1-MMP, an activator pro-MMP-2, in metanephric development. Also, its relationship with MMP-2 and its inhibitor,...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m809627200